imipenem brand name

This medicine is also used to treat hospital-acquired and ventilator-associated bacterial pneumonia. OTHER NAME(S): Imipenem-Cilastatin Suspension For Reconstitution Imipenem is a broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. It … Tore Midtvedt, in Side Effects of Drugs Annual, 2011. Cilastatin/imipenem systemic is used in the treatment of: Aspiration Pneumonia. 1907/2006 as amended by (EC) No. Several instances of cholestatic jaundice arising during or shortly after therapy have been reported with imipenem-cilastatin and other carbapenems. Overview. History of severe hypersensitivity to imipenem, cilastatin, or relebactam, or any other component. A recently published phase III study, The RESTORE IMI-1 demonstrated safety and tolerability in patients infected with carbapenem non-susceptible bacterial pathogens [ 3 ]. *Please select more than one item to compare Descriptions Imipenem, cilastatin, and relebactam combination injection is used to treat complicated bacterial infections in many different parts of the body (eg, kidneys, stomach). The drug is distributed rapidly and widely to most tissues and fluids, including sputum, pleural fluid, peritoneal fluid, interstitial fluid, bile, aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal fluid, and reproductive organs; low concentrations occur in CSF; it crosses the placenta, and enters breast milk. It is important tell one's doctor or pharmacist one's medical history, especially of brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, and stomach/intestinal diseases (e.g., colitis).[5]. Application Number. Drug Name : Imipenem and Cilastatin Imipenem and Cilastatin (Primaxin) generic is a … Imipenem/cilastatin is indicated for the treatment of severe or complicated skin, tissue, joint, respiratory tract, intra-abdominal, urinary tract and urogenital infections, but not meningitis (as it does not pass through the blood brain barrier), endocarditis, and sepsis due to susceptible organisms. cilastatin/imipenem systemic. Imipenem; Imipenem/cilastatin (Brand name: Primaxin) Doripenem (Brand name: Doribax) Meropenem (Brand name: Merrem) Ertapenem (Brand name: Invanz) Contents. Powder for solution for infusion 1 × 20ml Vial per pack. Available for Android and iOS devices. Because imipenem is rapidly inactivated by renal dehydropeptidase I, it is given in combination with cilastatin, a DHP-I inhibitor which increases half-life and tissue penetration of imipenem. Some patients may benefit from symptomatic therapy of the pruritus associated with cholestasis using antihistamines, ursodiol, or cholestyramine. Important: The information below refers to products available in the United States that contain imipenem. Bone infection. Imipenem/cilastatin has the ability to kill a wide variety of bacteria. Imipenem is in a class of medications called carbapenem antibiotics. Federal government websites often end in .gov or .mil. The liver injury due to the carbapenems is usually mild and self-limited. Bacteremia. Its chemical name is [5 R - [5α, 6α (R *)]]-6- (1-hydroxyethyl) -3- [ [2- [ (iminomethyl) amino] ethyl]thio]-7-oxo-1-azabicyclo [3.2.0] hept … The cause of the mild, transient serum enzyme elevations during imipenem-cilastatin therapy is not known. 500mg imipenem, 500mg cilastatin, and 20mg sodium bicarbonate power mixture for … Search results for Imipenem at Sigma-Aldrich. [3] It is on the World Health Organization's List of Essential Medicines. Intravenous: 250mg imipenem, 250mg cilastatin, and 10mg sodium bicarbonate power mixture for intravenous injection. The company that markets these medicines is Merck, Sharp & Dohme. Rarely, the carbapenems can cause a clinically apparent acute cholestatic hepatitis that is usually self-limiting and not requiring therapy or intervention. Imipenem/cilastatin/relebactam, sold under the brand name Recarbrio, is a fixed-dose combination medication used as an antibiotic. How to use imipenem in a sentence. Primaxin IM lacks the sodium bicarbonate buffer. Imipenem+Cilastatin+500500 Mg 1 Unit Parenteral Use. Imipenem is the active antibiotic agent and works by interfering with their ability to form cell walls, so the bacteria break up and die. The latency to onset has been within one to three weeks, and the pattern of enzyme elevations is usually cholestatic. Continue Learning about Antibiotic 6 Ailments That Call for an Antibiotic [5][6], Patients who are allergic to penicillin, cephalosporins, and related drugs may react to imipenem. Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage. Developmental toxicity studies with imipenem and cilastatin sodium (alone or in combination) administered to mice, rats, rabbits, and monkeys at doses 0.4 to 2.9 times the recommended human dose (RHD), (based on body surface area), showed no drug-induced fetal malformations [1] Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem. 1272/2008 1.1 Product Code: 16039 Section 1. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. [1] It is given by injection into a vein or muscle. [9] Chemical formula: C12H17N3O4SDrugbank ID: DB01598ATC code(s): J01DH51. [5][6], It is a broad-spectrum beta-lactam containing equal quantities of imipenem and cilastatin. For reasons that will be discussed, meropenem is not hydrolyzed by renal brush border dehydropeptidase. [2] Imipenem is in the carbapenem family of medications and works by interfering with the bacteria's cell wall. [6] Primaxin is cleared from the body by the kidneys, so it is important to tell one's doctor about any other drugs being taken that are also cleared through the kidneys (such as other antibiotics), especially for older patients, as kidney function declines with age. Buy Imipenem Online. Generic Name: Imipenem and Cilastatin (i mi PEN em & sye la STAT in) Brand Name: Primaxin I.V. Compare Products: Select up to 4 products. As a result, the antibiotic stays in the body and can work for longer. Imipenem (trade name Primaxin among others) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. Search results for imipenem at Sigma-Aldrich. Imipenem-Cilastatin SODIUM Vial Side Effects by Likelihood and Severity COMMON side effects. caused by various types of bacteria. Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. It works by helping i… In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicated intra-abdominal infections. - 500 INJECTION. [6], World Health Organization's List of Essential Medicines, "Cilastatin / imipenem Use During Pregnancy | Drugs.com", "Imipenem and Cilastatin Sodium Injection", https://en.wikipedia.org/w/index.php?title=Imipenem/cilastatin&oldid=983527147, World Health Organization essential medicines, Chemical pages without DrugBank identifier, Multiple chemicals in an infobox that need indexing, Drugs that are a combination of chemicals, Wikipedia medicine articles ready to translate, Srpskohrvatski / српскохрватски, Creative Commons Attribution-ShareAlike License, This page was last edited on 14 October 2020, at 19:00. In patients with vanishing bile duct syndrome, corticosteroids are often used but have not been shown to be beneficial and are best avoided. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. H2O that is derived from a bacterium (Streptomyces cattleya) and is effective against gram-negative and gram-positive bacteria. The recommended dosage is 250 mg to 1 gram given intravenously every 6 to 8 hours or in intramuscular doses of no more than 1.5 gm daily, usually for five to 14 days. Data sources include IBM Watson Micromedex (updated 2 Nov 2020), Cerner Multum™ (updated 2 Nov 2020), ASHP (updated 23 Oct 2020) and others. The cholestatic hepatitis attributed to imipenem-cilastatin and the carbapenems is probably immunoallergic and resembles the rare, clinically apparent liver injury that has been linked to penicillins and cephalosporins. Imipenem And Cilastatin (Intravenous Route, Intramuscular Route) Description and Brand Names - Mayo Clinic. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Its use is generally restricted to severe infections largely in hospitalized patients. [4], Imipenem/cilastatin is used for lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections, bacterial sepsis, bone and joint infections, skin and skin structure infections, endocarditis and polymicrobic infections. “Primaxin” the brand of Originator Merck & Co. contains Imipenem & Cilastatin, a new beta-lactam agent of the carbapenem class (1-Beta-methyl carbapenem). * Each vial contains: Imipenem monohydrate equivalent to 500 mg imipenem anhydrous, and Cilastatin sodium equivalent to 500 mg Cilastatin acid, with 21 mg Sodium Bicarbonate. *Please select more than one item to compare Primaxin is an antibiotic useful for the treatment of a number of bacterial infections. 750mg imipenem and 750mg cilastatin power mixture for intramuscular injection. Imipenem-cilastatin-relebactam Injection FDA Identified Breakpoints. Dosage Strength. If experienced, these tend to have a Severe expression. The brand name for imipenem and cilastatin is Primaxin. Imipenem (hydrate) SAFETY DATA SHEET Supersedes Revision: 10/28/2014 according to Regulation (EC) No. [1], Imipenem/cilastatin was first sold in 1987. [1] It is made from a combination of imipenem and cilastatin. Cilastatin is in a class of medications called dehydropeptidase inhibitors. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Brand names: Primaxin IV, Primaxin IMDrug class(es): carbapenemsCilastatin/imipenem systemic is used in the treatment of: Brand names: RecarbrioDrug class(es): carbapenems/beta-lactamase inhibitorsCilastatin/imipenem/relebactam systemic is used in the treatment of: → Search the entire Drugs.com site for imipenem. USES: This medication is used to treat a wide variety of bacterial infections.This medication is known as a carbapenem-type antibiotic. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. viridans- group streptococci, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species. View all Brand Names Innovator's Monograph Indications The activity of Cilastatin & Imipenem against an unusually broad spectrum of pathogens makes it particularly useful in the treatment of polymicrobic mixed aerobic/anaerobic infections as well as initial therapy prior to … Side Effects. [1] Specifically it is used for pneumonia, sepsis, endocarditis, joint infections, intra-abdominal infections, and urinary tract infections. BRAND NAME(S): Primaxin. GENERIC NAME(S): Imipenem-Cilastatin. It is given by injection into a vein or muscle. Recently, it was FDA approved for complicated intra-abdominal (cIA)and urinary tract infections (cUTI) under the brand name Recarbrio ®. Little information is available on possible cross-sensitivity to liver injury among the different betalactam antibiotics, but patients with clinically apparent liver injury due to imipenem should probably avoid the other carbapenems. Imipenem and other carbapenems have not been linked to cases of acute liver failure. Imipenem is a broad-spectrum betalactam antibiotic used for severe bacterial infections caused by susceptible organisms. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Imipenem (hydrate) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. 1.1 Related SourceWatch articles; 1.2 References; 1.3 External resources; 1.4 External articles; Articles and resources Imipenem/cilastatin, sold under the brand name Primaxin among others, is an antibiotic useful for the treatment of a number of bacterial infections. Imipenem and cilastatin injection is used to treat certain serious infections that are caused by bacteria, including endocarditis (infection of the heart lining and valves) and respiratory tract (including pneumonia), urinary tract, abdominal (stomach area), gynecological, blood, skin, bone, and joint infections. More serious hepatic injury from imipenem/cilastatin is rare, but jaundice and liver test abnormalities have been reported in 0.1% of patients in prospective trials of the agent. Brand names: Primaxin IV, Primaxin IM. Imipenem is rapidly degraded by the renal enzyme dehydropeptidase if administered alone (making it less effective); the metabolites can cause kidney damage. Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. The brand name of the imipenem-cilastatin combination is Primaxin, and the prescribed dose of Primaxin is understood to refer to the amount of the imipenem component being administered. Find imipenem at best price offered by imipenem manufacturers, imipenem suppliers, dealers, traders and exporters. Bacterial Infection. Imipenem/cilastatin was approved for use in the United States in 1985. The .gov means it’s official. Wide range of imipenem along with latest price, moq & product details Function and... Or relebactam, or any other component * Please select more than one item to compare Imipenem+Cilastatin+500500 1! … imipenem and cilastatin Imipenem+Cilastatin+500500 Mg 1 Unit Parenteral use 's cell wall diagnosis or.. 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